应用抗菌药物降低结膜囊细菌量的临床研究

Application of antimicrobial agents for reducing conj unctival sac bacterial flora

doi:
10.3969/j.issn.1671-9638.2014.11.009
摘要:
目的:探讨局部和全身应用抗菌药物对降低结膜囊细菌量的效果。方法随机抽取白内障患者82例(164眼)作为研究对象,同一患者的未手术眼为研究对照眼。术前3 d,手术眼用0.5%左氧氟沙星滴眼液点眼;术前30 min,患者全身应用抗菌药物。在以下时间采集双眼结膜囊标本,行细菌培养:入院时(T0);手术眼应用0.5%左氧氟沙星滴眼液3 d后(T1);患者全身应用抗菌药物30 min后(T2)。结果手术眼和对照眼T0、T1、T2结膜囊细菌培养阳性率分别为42.68%(35/82)、0(0/82)、0(0/82)和43.90%(36/82)、8.54%(7/82)、0(0/82)。结论局部或全身应用抗菌药物均可降低结膜囊细菌量。由于全身应用抗菌药物副作用大,不建议在常规白内障手术前应用。
Abstract:
Objective To evaluate the efficacy of topical and systemic antimicrobial application on reducing con-junctival sac bacterial flora. Methods 82 cataract patients (164 eyes)were randomly selected for studying,non-surgical eye of the same patient was as control eye. Surgical eyes received 3-day preoperative 0.5% levofloxacin eye drops,all patients received systemic antimicrobial agents 30 minutes before surgery. Specimens from conjunctival sac were collected at the following time points:admission (T0);3 days after receiving 0.5% levofloxacin eye drops before surgery (T1);30 minutes after all patients received systemic antimicrobial agents (T2),all specimens were performed bacterial culture. Results The percentage of positive cultures for surgical and control eyes was 42.68%(35/82)and 43.90% (36/82)at T0,0 (0/82)and 8.54% (7/82)at T1,0(0/82)and 0 (0/82)at T2,respectively. Conclusion Topical and systemic antimicrobial application can reduce conjunctival sac bacteria. Because of the side effects of systemic antimicrobial agents,preoperative routine systemic antimicrobial use is not suggested.
作者 杨砚亭    卢国华
Author: YANGYan-ting    LUGuo-hua
作者单位 南京医科大学附属常州第二人民医院,江苏 常州,213000
刊 名: 中国感染控制杂志   ISTIC
Journal: Chinese Journal of Infection Control
年,卷(期) 2014, (11)
分类号 R779.66
关键词: 白内障 知识脉络    结膜囊 知识脉络    细菌 知识脉络    抗菌药物 知识脉络    合理用药 知识脉络    抗感染 知识脉络   
Keywords: cataract    conj unctival sac    bacteria    antimicrobial agent    rational drug use    anti-infection   
机标分类号 R76 R71
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